August 16, 2021
Great news!! Our R01 to study the "Mechanism of Myosin-based Filopodia Formation" has been successfully renewed for four more years by NIGMS NIH!!
The renewal of this grant is thanks to the dedicated and tremendous work of TLab members and awesome collaborators over the past 5 - 6 years, resulting in several key discoveries and papers. Thanks to you all and looking forward to four more years of filopodia myosin fun!
(and another big thanks to NIGMS for the continued support of our research)
Great news!! Our R01 to study the "Mechanism of Myosin-based Filopodia Formation" has been successfully renewed for four more years by NIGMS NIH!!
The renewal of this grant is thanks to the dedicated and tremendous work of TLab members and awesome collaborators over the past 5 - 6 years, resulting in several key discoveries and papers. Thanks to you all and looking forward to four more years of filopodia myosin fun!
(and another big thanks to NIGMS for the continued support of our research)
August 6, 2021
The lab has received an equipment supplement to upgrade our shiny new Nikon Ti2 to a spinning disc confocal. Looking forward to collecting alot of data of our awesome Dicty making filopdodia.
Thank you NIGMS NIH for support of our work!
The lab has received an equipment supplement to upgrade our shiny new Nikon Ti2 to a spinning disc confocal. Looking forward to collecting alot of data of our awesome Dicty making filopdodia.
Thank you NIGMS NIH for support of our work!
May 24, 2021
BIG review on myosins in filopodia, microvilli and stereocilia is published in Current Biology as part of a Special Issue on the Cytoskeleton.
BIG review on myosins in filopodia, microvilli and stereocilia is published in Current Biology as part of a Special Issue on the Cytoskeleton.
May 20, 2021
Congratulations to our former grad student Ashley - the last half of her thesis work on VASP-mediated recruitment of DdMyo7 as an essential step in filopodia formation is accepted for publication in eLife!!!!!! A big shout-out to Amy who provided absolutely critical data for the paper revision.
Congratulations to our former grad student Ashley - the last half of her thesis work on VASP-mediated recruitment of DdMyo7 as an essential step in filopodia formation is accepted for publication in eLife!!!!!! A big shout-out to Amy who provided absolutely critical data for the paper revision.
March 22, 2021
Our fun collaboration with the Fritz-Laylin lab (UMass, Amherst) to look at actin cytoskeleton-associated genes in chytrid fungi is published in Current Biology.
Really looking forward to learning all about what the myosins do in these cool critters.
Our fun collaboration with the Fritz-Laylin lab (UMass, Amherst) to look at actin cytoskeleton-associated genes in chytrid fungi is published in Current Biology.
Really looking forward to learning all about what the myosins do in these cool critters.
March 9, 2021
Casey's NIH F31 Predoctoral fellowship from NIGMS is funded. CONGRATULATIONS!!!! Well done.
Casey's NIH F31 Predoctoral fellowship from NIGMS is funded. CONGRATULATIONS!!!! Well done.
February 16, 2021
Casey presented his poster on "Characterization of a filopodia myosin motor" at the virtual Biophysics Meeting.
Casey presented his poster on "Characterization of a filopodia myosin motor" at the virtual Biophysics Meeting.
December 31, 2020
Our long-time collaborator Dr Anne Houdusse (Institut Curie) is awarded "Ordre national du Mérite au grade de chevalier " by the French Academy of Science for her important mechanistic and structural work on myosin motors.
Congratulations, Anne!
Our long-time collaborator Dr Anne Houdusse (Institut Curie) is awarded "Ordre national du Mérite au grade de chevalier " by the French Academy of Science for her important mechanistic and structural work on myosin motors.
Congratulations, Anne!
September 1, 2020
Annnika is headed to Northwestern to start the PhD program in the Biomedical Science program. Good luck Annika!
August 24, 2020
Maham Zia, a recent Reed College Physics graduate, joins the lab as a Researcher 1.
Great to have you working with us Maham!
Maham Zia, a recent Reed College Physics graduate, joins the lab as a Researcher 1.
Great to have you working with us Maham!
July 30, 2020
Our new paper with Hanna Brzeska and Ed Korn (NHLBI, NIH) on "Dictyostelium myosin 1F and myosin 1E inhibit actin waves in a lipid‐binding‐dependent and motor‐independent manner" is now online in Cytoskeleton.
Our new paper with Hanna Brzeska and Ed Korn (NHLBI, NIH) on "Dictyostelium myosin 1F and myosin 1E inhibit actin waves in a lipid‐binding‐dependent and motor‐independent manner" is now online in Cytoskeleton.
July 21, 2020
Ashley Arthur successfully defended her PhD thesis on MyTH-FERM Myosin based filopodia initiation.
Ashley was awarded an NIH F32 Postdoctoral Fellowship from NIGMS to pursue work in the Howard Lab at Yale University. Good luck Ashley! Looking forward to more great science from you in the future (even if it will be on microtubules...).
Ashley was awarded an NIH F32 Postdoctoral Fellowship from NIGMS to pursue work in the Howard Lab at Yale University. Good luck Ashley! Looking forward to more great science from you in the future (even if it will be on microtubules...).
July 1, 2020
Amy Crawford joins us as a Researcher 1, another awesome Gustavus Adolphus alumnus (class of 2020) working in the Titus lab.
Welcome aboard Amy!
Amy Crawford joins us as a Researcher 1, another awesome Gustavus Adolphus alumnus (class of 2020) working in the Titus lab.
Welcome aboard Amy!
January 20, 2020
Our collaborative work with Hanna Brzeska and Ed Korn (NHLBI, NIH) on "Basic-hydrophobic sites are localized in conserved positions inside and outside of PH domains and affect localization of Dictyostelium myosin 1s" is published in MBoC.
Our collaborative work with Hanna Brzeska and Ed Korn (NHLBI, NIH) on "Basic-hydrophobic sites are localized in conserved positions inside and outside of PH domains and affect localization of Dictyostelium myosin 1s" is published in MBoC.
October, 2019
More well-deserved recognition - our collaborator Dr Anne Houdusse (Institut Curie) has been selected as a Member of the French Académie des Sciences, section Molecular Biology, Cell Biology and Genomics.
More well-deserved recognition - our collaborator Dr Anne Houdusse (Institut Curie) has been selected as a Member of the French Académie des Sciences, section Molecular Biology, Cell Biology and Genomics.
October 21, 2019
Biswaprakash Mahanta (MCDB&G Grad program) joins the Titus lab for a rotation to learn all about the way of the amoeba and its filopodia myosin.
Biswaprakash Mahanta (MCDB&G Grad program) joins the Titus lab for a rotation to learn all about the way of the amoeba and its filopodia myosin.
October 19, 2019
Our new paper "Optimized filopodia formation requires myosin tail domain cooperation" is published in PNAS
Our new paper "Optimized filopodia formation requires myosin tail domain cooperation" is published in PNAS
August 23, 2019
It's Livia's last day in the Titus Lab - she is heading off to Graduate Study in Biology program at UCSD. Best of luck! Looking forward to all of the cool science you'll be doing in the future.
It's Livia's last day in the Titus Lab - she is heading off to Graduate Study in Biology program at UCSD. Best of luck! Looking forward to all of the cool science you'll be doing in the future.
July 29 2019
Meg gave a talk at GRC - Motile and Contractile Systems meeting highlighting Ashley's work on MF Myosin and VASP cooperation during filopodia formation
Meg gave a talk at GRC - Motile and Contractile Systems meeting highlighting Ashley's work on MF Myosin and VASP cooperation during filopodia formation
June 17 2019
Annika Schroder joins us as a Researcher 1, continuing the tradition of awesome Gustavus Adolphus alumni (class of 2019) working in the Titus lab.
Welcome aboard Annika!
Annika Schroder joins us as a Researcher 1, continuing the tradition of awesome Gustavus Adolphus alumni (class of 2019) working in the Titus lab.
Welcome aboard Annika!
June 16 2019
Ashley heads off to the world-famous Physiology Course at the Marine Biological Laboratory in Woods Hole, MA - a third generation Physiology Course Student and/or Faculty!
The T lab takes on the Zumbro river!
3 June, 2019
Heidi P joins the lab as a participant in the summer LSSURP
program to perform genomic engineering on true wild type
Dictys.
May 18, 2019 
Dr Mike Ostap (https://www.med.upenn.edu/ostaplab/) presents the keynote at the Minnesota Muscle symposium and the Titus lab presented posters at the poster session
Dr Mike Ostap (https://www.med.upenn.edu/ostaplab/) presents the keynote at the Minnesota Muscle symposium and the Titus lab presented posters at the poster session
January 18, 2019
Hibo received an Undergraduate Reseach award (UROP) for her proposal to engineer amoeba's using CRISPR
Hibo received an Undergraduate Reseach award (UROP) for her proposal to engineer amoeba's using CRISPR
December 14, 2018
Our awesome collaborator Dr Anne Houdusse (Institut Curie) is awarded the prestigious Jean-Pierre Lecocq Prize from the Institut de France Académe de Sciences for her important work on the molecular mechanism of myosin motor force generation and understanding how drugs developed for the treatment of cardiovascular disease impact motor function.
Congratulations, Anne!
Our awesome collaborator Dr Anne Houdusse (Institut Curie) is awarded the prestigious Jean-Pierre Lecocq Prize from the Institut de France Académe de Sciences for her important work on the molecular mechanism of myosin motor force generation and understanding how drugs developed for the treatment of cardiovascular disease impact motor function.
Congratulations, Anne!
December 1-5, 2018
Meg co-chaired a subgroup on Evolutionary Cell Biology with Holly Goodson (Notre Dame), and Ashley and Livia presented posters at ASCB meeting in San Diego, CA
Meg co-chaired a subgroup on Evolutionary Cell Biology with Holly Goodson (Notre Dame), and Ashley and Livia presented posters at ASCB meeting in San Diego, CA
November 26, 2018
Ashley imaged amoebas on Airyscan with Dr. Jordan Beach at Loyola University.
Ashley imaged amoebas on Airyscan with Dr. Jordan Beach at Loyola University.
November 5, 2018
Taylor Harding joins the lab for a postdoctoral fellow project. Welcome, Taylor!
Taylor Harding joins the lab for a postdoctoral fellow project. Welcome, Taylor!
Ashley gave a short presentation at the GCD retreat, and won a cell biology award and a travel award from the annual DBC symposium for best graduate student poster.
September 10, 2018
Krisna Van Dyke (MCDB&G Grad program) joins the Titus lab for a rotation, welcome Krisna!
Krisna Van Dyke (MCDB&G Grad program) joins the Titus lab for a rotation, welcome Krisna!
September 1, 2018
Dr. Benjamin Binder joins Ausberg for a job as Assistant Professor in the Department of Chemistry. Congrats Ben, good luck!
Dr. Benjamin Binder joins Ausberg for a job as Assistant Professor in the Department of Chemistry. Congrats Ben, good luck!
A 
ugust 9, 2018
Cierra presented her work at the LSSURP symposium. She's headed back to Hampton University after a great summer. Good luck, Cierra.
Cierra presented her work at the LSSURP symposium. She's headed back to Hampton University after a great summer. Good luck, Cierra.
July 10, 2018
Ashley gave a talk about her work "MyTH FERM myosin and VASP cooperation during filopodia formation" at the GRC cytoskeletal motors conference in Dover, Vermont and will chair the GRS for the meeting in 2020.
Ashley gave a talk about her work "MyTH FERM myosin and VASP cooperation during filopodia formation" at the GRC cytoskeletal motors conference in Dover, Vermont and will chair the GRS for the meeting in 2020.
June 15, 2018
Cierra A joins us for a summer project with the LSSURP program, welcome, Cierra!
Cierra A joins us for a summer project with the LSSURP program, welcome, Cierra!
May 30, 2018
Livia Songster was promoted to lab technician and will continue her work in the lab studying the role of MyTH FERM myosin dimerization in filopodia formation.
Livia Songster was promoted to lab technician and will continue her work in the lab studying the role of MyTH FERM myosin dimerization in filopodia formation.
March 31, 2018 
Livia Songster was awarded a travel grant to attend NCUR and presented her poster "Role of MyTH4 FERM Myosin in filopodia initiation within Dictyostelium discoideum"
Livia Songster was awarded a travel grant to attend NCUR and presented her poster "Role of MyTH4 FERM Myosin in filopodia initiation within Dictyostelium discoideum"
March 30, 2018
Casey Eddington joined the Titus Lab from the BMBB graduate program. Welcome, Casey!
Casey Eddington joined the Titus Lab from the BMBB graduate program. Welcome, Casey!
March 26, 2018
DR. Ben Binder joined the Titus Lab for a postdoctoral position prior to his faculty job at Augsburg University in Fall!
DR. Ben Binder joined the Titus Lab for a postdoctoral position prior to his faculty job at Augsburg University in Fall!
March 1, 2018
The review on "Myosin-Driven Intracellular Transport" in Cold Spring Harbor Perspectives in Biology is now online.
The review on "Myosin-Driven Intracellular Transport" in Cold Spring Harbor Perspectives in Biology is now online.
Feb 1, 2018
Ashley Arthur was awarded an F31 fellowship from NIGMS for her project studying DdMyo7 and VASP cooperation in filopodia formation.
Ashley Arthur was awarded an F31 fellowship from NIGMS for her project studying DdMyo7 and VASP cooperation in filopodia formation.
January 1, 2018
Titus Lab Alum Dr Karl Petersen was awarded the prestigious Marie-Skłodowska-Curie Actions - Individual Fellowship from the European Commission. Well done, Karl!
Dec 2017
Awesome Titus lab member Livia Songster was awarded a UROP undergraduate research award for her project on the DdMyo7 Lever arm. Congrats, Livia!
Awesome Titus lab member Livia Songster was awarded a UROP undergraduate research award for her project on the DdMyo7 Lever arm. Congrats, Livia!
June 29, 2017
Our collaborative paper with the Houdusse lab “Myosin 7 and its adaptors link cadherins to actin” is published in Nature Communications.
Our collaborative paper with the Houdusse lab “Myosin 7 and its adaptors link cadherins to actin” is published in Nature Communications.
June 1, 2017
We were awarded a four-year NIH grant from NIGMS to support our project the Mechanism of myosin motor-dependent filopod extension.
Hooray!
Hooray!
April 27, 2017
December 13, 2016
Our major paper describing the conserved roles of MyTH-FERM myosins in filopodia formation is published in PNAS.
Our major paper describing the conserved roles of MyTH-FERM myosins in filopodia formation is published in PNAS.
December 9, 2016-
Congrats Dr. Karl Petersen on your Ph.D. Thesis! "Structure-Function Analysis of Motor Proteins: Insights from Conventional and Unconventional Myosins" Advisors Dr. Margaret Titus & Dr. David Thomas. Best wishes as you continue your career in the Houdusse lab at Institut Curie in Paris, France.
June 1, 2016
We were awarded a two-year AHA Grant-In-Aid for the project entitled: Mechanism of myosin motor-dependent filopod extension.
We were awarded a two-year AHA Grant-In-Aid for the project entitled: Mechanism of myosin motor-dependent filopod extension.
May 24, 2016
Our collaborative paper with the Houdusse lab describing the structure of DdMyo7 MyTH-FERM domains revealing the convergent evolution of these domains is published in PNAS.
Our collaborative paper with the Houdusse lab describing the structure of DdMyo7 MyTH-FERM domains revealing the convergent evolution of these domains is published in PNAS.